Dermal fillers are a group of non-toxic substances that are injected under the skin at various depths to smooth out fine lines, deep wrinkles, nasolabial folds, and acne scars, volumize and define lips, contour the chin and nose, or plump up sunken cheeks or temples for a full, lifted appearance.

    Perlane (Medicis) is a thicker dermal filler than it’s sister brand Restalyne (also made my Medicis), designed to treat severe wrinkles around the forehead, nose, and lips, and can also significantly improve facial depressions in the cheeks, chin, and under-eye area. Perlane reduces the severity of deep nasolabial folds (the lines from your nose to the corners of your mouth) or marionette lines (the lines from the corners of your mouth down toward your jawline), redefine the lip border, and soften depressed scars. Perlane is also used as a hand rejuvenation treatment. Perlane-L is the same formula with added lidocain, an anesthetic, to minimize discomfort during and after the treatment.

    Perlane is made with a hyaluronic acid gel. “Hyaluronic acid is a sugar that’s found naturally in your skin and makes your joint spaces feel slippery. Its function is to absorb water, deliver nutrients, and act as a cushioning agent. So when you inject it into your skin, it acts like a sponge and expands to fill in wrinkles and folds and support sunken areas,” explains Dr. Debra Wattenberg, who specializes in cosmetic dermatology in her New York City boutique clinic, SkincareRX, and is an associate clinical professor of dermatology at Mount Sinai Hospital. The extra water brought to the skin’s surface also imparts a fresh, glowing radiance and a soft, supple skin texture. These injections induce a robust production of collagen, which helps to further firm and plump your skin and reduce wrinkles over time.

    There are various brands of fillers comparable to Perlane, and they all have slightly different compounds and consistencies and are designed to be injected at various depths within your skin. It’s really up to your cosmetic doctor to choose which ones are best to address your issues, but in general, Perlane is thicker than Belotero, Restalyne and Juvederm Ultra, and pretty equivalent to Juvederm Ultra Plus. It is meant to be injected into the deep layers of the dermis to correct severe wrinkles and folds. In many cases, a combination of two or more dermal filler brands applied to different areas will be most effective for optimal facial rejuvenation.

    A few words of caution: “If a hyaluronic acid based dermal filler gets inadvertently injected into a blood vessel, it can cause some significant side effects such as skin breakdown, ulceration, or necrosis of the skin. Thankfully, a quick injection of hyaluronidase, can enzyme, an immediately reverse those negative effects,” explains Dr. Wattenberg. It’s important you go to a qualified cosmetic doctor who can quickly diagnose this type of situation and administer the antidote. Browse The Book for the best experts in your city. Improper injections can also result in an infection.


    Perlane treatments show results on all skin types and skin colors, but are ideal for those seeking to add significant volume, smooth deeper lines and folds, and plump areas with moderate to deep skin depression or fat loss. They are also ideal for those seeking to rejuvenate the skin on their hands.

    Women who are pregnant or breastfeeding should not use dermal fillers. Anyone who has recently used blood thinners or has a bleeding disorder should also avoid dermal fillers. You should be cautious if you’ve had previous bad allergic reactions that have required in-hospital treatment.


    Perlane treatments are fast and relatively painless. Typically, a local or topical anesthetic is first applied to eliminate any discomfort. Once that takes effect, the filler, a thin gel-like substance, is injected into the target area using a tiny, fine needle.


    15 to 40 minutes


    The most common side effects after Perlane treatments include temporary redness, tenderness, swelling, and bruising at the injection site. Makeup may be applied immediately to cover up any redness, but it takes 3 days to a week for effects to completely resolve.

    In rare cases, small bumps may appear under the skin at the injection site. If they don’t dissipate within a week, check back in with your doctor.


    “Everyone experiences a different reaction with dermal fillers. A little bit of Perlane can do a lot for one person, while it may do very little in someone else,” warns Dr. Wattenberg. The results of one Perlane injection should be immediate, with continuous correction as new collagen regenerates. The area of injection should instantly appear smoother and fuller, with more volume and definition than before receiving the treatment.


    One injection of Perlane should last 6 months to 1 year, depending on how fast your body naturally breaks down the filler. A maintenance treatment every 1 to 2 years will yield continuous results. Over time, you may actually need less frequent visits and smaller doses thanks to the long-term benefits of creating new collagen.


    You should only visit an actively board certified dermatologist or plastic surgeon. Dermatologists should be certified by the American Board of Dermatology (ABD). Plastic Surgeons should be certified by the American Board of Plastic Surgery (ABPS). Both of those boards are part of the American Board of Medical Specialties (ABMS), a non-profit organization that is considered the gold standard of physician certification. Consult the Charlotte’s Book Premier Provider directory to find a doctor who meets these standards and specializes in this treatment. For more information about how we choose our providers, please read Credentials We Abide By.


    $450 to $3,000 depending on how many injections you need.


    Even the strongest dermal filler can’t fix loose sagging skin around your neck, so thoughtfully referred to as a turkey gobbler. Be cautious to avoid over-filling your face in an effort to do so, or else you’ll distort your natural, beautiful features.

    To decrease your risk of bruising after treatment avoid aspirin, ibuprofen, vitamin E, or St. John’s Wort for 1 week prior to your treatment. Apply ice to the treated area for a day or two after getting injected.

    Perlane should not be injected into your lips because its thick consistency could result in lumpy results.



    Disclaimer: As always, this information is provided to you for educational and/or informational purposes only, and should not be construed as an endorsement of any particular product, treatment, or procedure. This information is not a substitute for medical advice, diagnoses, or treatment by a doctor or other qualified health care professional. For medical concerns, including decisions about any procedure or treatment, users should always consult their doctor or other qualified health care professional. Please visit our Terms of Service to view our full disclaimers.