Dermal fillers are a group of non-toxic substances that are injected under the skin at various depths to smooth out fine lines, deep wrinkles, nasolabial folds, and acne scars, volumize and define lips, contour the chin and nose, or plump up sunken cheeks or temples for a full, lifted appearance.

    Restylane (Medicis Aesthetic) is primarily used to treat medium-depth wrinkles, such as nasolabial folds (the lines from your nose to the corners of your mouth) and marionette lines (the lines from the corners of your mouth down toward your jawline). It may also be injected around the corners of the mouth or in the lips to add fullness and enhanced definition. Sometimes Restalyne is used as a hand rejuvenation treatment. Restylane-L is the same formula with added lidocain, an anesthetic, to minimize discomfort during and after the treatment.

    Restylane is made with a hyaluronic acid gel. “Hyaluronic acid is a sugar that’s found naturally in your skin and makes your joint spaces feel slippery. Its function is to absorb water, deliver nutrients and act as a cushioning agent. So when you inject it into your skin, it acts like a sponge and expands to fill in wrinkles and folds and support sunken areas,” explains Dr. Debra Wattenberg, who specializes in cosmetic dermatology in her New York City boutique clinic, SkincareRX, and is an associate clinical professor of dermatology at Mount Sinai Hospital. The extra water brought to the skin’s surface also imparts a fresh, glowing radiance and a soft, supple skin texture. These injections also induce a robust production of collagen, which helps to further firm and plump your skin and reduce wrinkles over time.

    There are various brands of fillers comparable to Restylane, and they all have slightly different compounds and consistencies and are designed to be injected at various depths within your skin. It’s really up to your cosmetic doctor to choose which ones are best to address your issues, but in general, Restylane is thicker than Belotero, pretty equivalent to Juvederm Ultra, and thinner than Juvederm Ultra Plus and Perlane. It’s meant to be injected into your dermis layer to correct medium-depth wrinkles and folds. In many cases, a combination of two or more dermal filler brands applied to different areas will be most effective for optimal facial rejuvenation.

    A few words of caution: “If a hyaluronic acid based dermal filler gets inadvertently injected into a blood vessel, it can cause some significant side effects such as skin breakdown, ulceration, or necrosis of the skin. Thankfully, a quick injection of hyaluronidase, an enzyme, can immediately reverse those negative effects,” explains Dr. Wattenberg. It’s important you go to a qualified cosmetic doctor who can quickly diagnose this type of situation and administer the antidote. Browse The Book for the best experts in your city. Improper injections can also result in an infection.


    Restylane treatments are ideal for those seeking to smooth medium-depth wrinkles and folds, and plump areas with minor skin depression or fat loss. Restalyne offers subtle results, so those wishing to fill deep-set wrinkles or folds should consider more vigorous treatments, such as Juvederm Ultra Plus or Perlane.

    Women who are pregnant or breastfeeding should not use dermal fillers. Anyone who has recently used blood thinners or has a bleeding disorder should also avoid dermal fillers. You should be cautious if you’ve had previous bad allergic reactions that have required in-hospital treatment. 


    Restylane treatments are fast and relatively painless. Typically, a topical anesthetic is first applied to eliminate any discomfort. Once that takes effect, the filler, a thin gel-like substance, is injected into the target area using a tiny, fine needle.


    10 to 30 minutes


    There is no downtime associated with Restylane treatments. Immediate side effects are minimal and may include temporary redness, tenderness, swelling, or bruising at the injection site, which can easily be concealed by makeup.

    In rare cases, small bumps may appear under the skin at the injection site. If they don’t dissipate within a week, check back in with your doctor.


    Everyone can experience different results. A dose in one woman can result in a dramatic change, while it may have a very minimal impact on someone else. The effects of Restylane should be immediately visible, with continuous correction as new collagen regenerates. The area of injection should instantly appear smoother and fuller, with more volume and definition than before receiving the treatment.


    One injection of Restylane tends to last 4 to 12 months, depending on how fast your body naturally breaks it down. 1 to 2 treatments per year should be sufficient to help maintain results. Over time, you may actually need less frequent visits and smaller doses thanks to the long-term benefits of creating new collagen.


    You should only visit an actively board certified dermatologist or plastic surgeon. Dermatologists should be certified by the American Board of Dermatology (ABD). Plastic Surgeons should be certified by the American Board of Plastic Surgery (ABPS). Both of those boards are part of the American Board of Medical Specialties (ABMS), a non-profit organization that is considered the gold standard of physician certification. Consult the Charlotte’s Book Premier Provider directory to find a doctor who meets these standards and specializes in this treatment. For more information about how we choose our providers, please read Credentials We Abide By.


    $450 to $3000 depending on how many injections you need.


    Juvederm Ultra is more hydrophilic than Restylane, which means it attracts more water resulting in a “puffier” appearance. That’s why some doctors may prefer to use Juvederm Ultra in younger lips and Restylane for older or more sun damaged lips.

    To decrease your risk of bruising after treatment, avoid aspirin, ibuprofen, vitamin E, or St. John’s Wort for 1 week prior to your treatment. Apply ice to the treated area for a day or two after getting injected.

    If a rash or pimple pops up in the area that you want to treat on injection day, postpone your treatment until it heals completely. A dermal filler injection could delay healing or make your skin problems even worse.



    Disclaimer: As always, this information is provided to you for educational and/or informational purposes only, and should not be construed as an endorsement of any particular product, treatment, or procedure. This information is not a substitute for medical advice, diagnoses, or treatment by a doctor or other qualified health care professional. For medical concerns, including decisions about any procedure or treatment, users should always consult their doctor or other qualified health care professional. Please visit our Terms of Service to view our full disclaimers.