Last year about 6.6 million Botulinum Toxin A injections were administered (Botox, Dysport, Xeomin). Line freezers are by far the most popular minimally invasive cosmetic procedure in the United States. As a comparison, dermal fillers came in second place, but they only totaled up to 2.3 million procedures, according to the American Society of Plastic Surgeons. We get it. Who doesn't want to look lineless, timeless, ageless—whatever you want to call it—forever? So there's no surprise that skincare companies have been racing to figure out how to offer Botox-like results at home. And, believe it or not, we might just be there, thanks to the development of neuropeptides. "Every decade we come closer to actually creating skincare that lives up to women's expectations," says Jules Zecchino, one of the country's leading chemists. As the top scientist at Estée Lauder for 18 years, and formulating for Avon and Elizabeth Arden before that, his résumé reads like a skincare encyclopedia—from Estée Lauder's Perfectionist, Idealist, and Advanced Night Repair lines to Clinique's Moisture Surge and Elizabeth Arden's Ceramide Capsules. He knows his stuff. "In the 80's it was all about retinoids and how they bolster collagen production. The 90's were all about alpha hydroxyl acids and smoothing the skin. Then peptides started becoming more advanced. Peptides target certain cells and tell them to do certain things," explains Zecchino. There's a whole host of different kinds of peptides that do different things, from improving collagen to reducing inflammation, but the most recent peptide development is a true breakthrough: neuropeptides.